DNA-based Investigations

The cornerstones of our DNA based investigative technology are the SYNLAB microID and microST platforms. The extensive knowledge and expertise that SYNLAB have developed and built around these platforms supports our position as the UK Market leader in Investigative Microbiology using bespoke DNA analysis.

SYNLAB microID is an accredited microbial identification methodology using 16s or 28s rRNA gene sequencing. The sequence of DNA acts as a unique barcode identifier for each organism giving fast, accurate results.

SYNLAB microST uses the method of MLST (Multi Locus Sequence Typing) to offer the most powerful and robust tool to track contaminants within the factory environment (both spatially and temporally).

Our expertise in interpreting and characterising the generated data allows the SYNLAB team to resolve a very wide range of projects using ‘gold standard’ bio-informatics tools.

Typically the SYNLAB microID methodology would be used in the identification of spoilage organisms, food-borne pathogens, sterility failures, product release screens, verification of sterile filling and the safety of high risk manufacturing platforms.

In a deeper crisis where there is an incident of factory or product contamination there can often be a requirement to investigate to sub-species level. In these cases SYNLAB microST technology is a powerful tool, which uses the comparison of short sequences of DNA to determine the relatedness of strains of the same species both in time and space. This method assists in the accurate pinpointing of the contamination source within a factory or a supply chain, specifically where there is the possibility of more than one source of contamination.